Effects of Crystal Meth on the Brain and Central Nervous System

Methamphetamine (d-methamphetamine, crystal meth, or meth) is a man-made central nervous system stimulant. The substance often appears as bluish-tinted or white rocks or pieces of glass. It is most commonly smoked or snorted, and it is manufactured in private home laboratories using pseudoephedrine or ephedrine along with other substances that can be purchased at drugstores or hardware stores.

The National Institute on Drug Abuse (NIDA) and the United States Drug Enforcement Administration (DEA) report that meth is a highly addictive substance, and its use is associated with a number of severe consequences.

How Meth Works in the Brain

The mechanism of action of the drug is similar to other stimulants, in that met use results in massive releases of the neurotransmitters norepinephrine and dopamine (along with other neurotransmitters) that lead to a number of extremely powerful euphoric effects, increases in energy, feelings of invulnerability, and other psychoactive effects. Because the substance is often made with a number of other substances that are potentially toxic, such as antifreeze, battery acid, or drain cleaner, it is both dangerous to use and highly combustible, making it dangerous to manufacture. Research regarding the short-term and long-term effects of methamphetamine use indicates that there are a number of significant potential dangers associated with its use, including significant neurological effects.

Effects on the Central Nervous System & Brain

The central nervous system (CNS) is composed of the brain and spinal cord. It serves as the major relay station for the body and is involved in the actions, regulation, and maintenance of nearly every bodily function. Research looking at the effects of methamphetamine focus primarily on the effects that occur in the brain; however, some of these effects can also be expected to generalize to neurons located in the spinal cord. The nerves located in the CNS are referred to as neurons, whereas the nerves outside the CNS are simply referred to as nerves.

Increased neuronal death

The use of methamphetamine is associated with decreases in the number of neurons in the CNS. The ability of the CNS to regenerate these neurons is limited, and in many cases, the loss of neurons cannot be recovered. The body of evidence indicates that chronic use of methamphetamine can result in diffuse brain damage that occurs via neuronal death. Neuronal death occurs in a number of areas of the brain as a result of meth use that include but are not limited to:

• The hippocampus: a crucial structure for the ability to remember and learn new information
• The striatum: a structure in the subcortical areas of the brain that is crucial in movement and certain aspects of directed attention
• The parietal cortex: a structure that is involved in being able to visualize objects in space and in the memory of nonverbal material
• The frontal and prefrontal cortex: areas of the brain that are crucial in human cognition, particularly in reasoning, complex attention, problem-solving, and the inhibition of behaviors that might be damaging
• A number of subcortical structures: including the basal ganglia, the reward center, the limbic system, and others
• The cerebellum: controls various aspects of movement and is involved in a number of cognitive functions

Decreased Gliogenesis

Neurons are not the only cells in the CNS. A number of other cells generally referred to as glial cells also comprise the central nervous system. These cells have a number of responsibilities, including signaling capacities, fighting infection, developing myelin (the fatty sheath or white matter that neurons used to effectively communicate), etc. The use of methamphetamine has also been associated with increased damage and death to these cells in a number of brain areas, particularly in the prefrontal cortex where a number of important functions, such as attention, planning, abstract thinking, judgment, etc., occur. In addition, methamphetamine use is associated with a decrease in the production of glial progenitor cells, which are immature glial cells that differentiate into different types of glial cells.

Decreased White Matter

As certain glial cells (oligodendrocytes and Schwann cells) become damaged and the ability to produce myelin is affected in both the brain and spinal cord, the amount of white matter in the CNS is decreased. White matter (myelin) aids in efficient singling between neurons in the CNS. White matter is located on the axons (signaling portions) of the neurons, and as this matter is decreased, neurons become less efficient in transmitting their signals. This results in a number of functional deficits.

Decreases in the Levels of Dopamine and Serotonin Transporters

Dopamine and serotonin transporters are specialized cells in the CNS that function to remove the dopamine and serotonin that have been released from the neurons into the synaptic cleft (the space between neurons) and bring them back into the cell where they can be repackaged for reuse. This partially results in the psychoactive effects of meth, but also leads to later dopamine and serotonin depletion because the neurons have less dopamine to use later. This can result in a number of extreme mood effects, such as initial extreme euphoria followed by extreme periods of depression, apathy, and hopelessness.

Increased Glutamate Calcium in the Brain

Increases in the neurotransmitter glutamate (the major excitatory neurotransmitter in the brain) and calcium are often associated with neurotoxic effects in the brain as a result of the neurons being overly excited and continuing to fire to the point of actually damaging the system. If not modulated, this can result in significant damage throughout the central nervous system.

Neurotoxic Effects that Damage the Dendrites of the Neurons

A number of these neurotoxic effects lead to significant damage in the dendrites of neurons. The dendrites of neurons are the receiving portions of the neurons that receive the chemical singles from other neurons. This damage prevents the neurons from communicating effectively and can affect a number of cognitive and motor functions.

Cytoskeletal Damage

The support system in the cells is also damaged by use of methamphetamine. This can result in cellular collapse if the support structures are significantly damaged.

Damage to the Circulatory System of the Brain

Use of methamphetamine also affects the veins, arteries, and capillaries in the central nervous system via issues associated with increased blood pressure, weakening veins and arteries, leaving them open to clots, and scarring them. This results in an increased potential for an individual to have a stroke. Strokes in the central nervous system are often classified as ischemic or hemorrhagic. Ischemic strokes occur as a result of depletion of blood to certain areas of the brain and the accumulation of damage to the tissues as a result of depleted oxygen over time. This situation is a chronic one and often associated with permanent effects. Hemorrhagic strokes occur as a result of the breaking of an artery or vein in the brain and the resulting reduction in blood flow to the tissues of the brain. Hemorrhagic strokes are typically more acute, and recovery from hemorrhagic strokes is generally more robust than recovery from ischemic strokes. Both ischemic strokes and hemorrhagic strokes can develop as a result of chronic methamphetamine use. This presents an extremely complicated issue.

Is Brain Damage from Meth Permanent?

Individuals who use drugs like methamphetamine are often at greater risk to have accidents or become involved in assaults that lead to traumatic brain injuries. Of course, having the combination of a traumatic brain injury and a chronic history of methamphetamine use will result in a number of potentially serious neurological issues.

Some of the above effects may resolve, and there may be some improvement over time. For example, research indicates that damage to the dopamine transporter system may repair over time with significant abstinence. However, there is quite a bit of individual variability that occurs in the recovery process, largely depending on the severity and duration of someone’s chronic methamphetamine use.

Cognitive, Behavioral, & Psychological Effects of Meth Use

The list of cognitive and emotional effects that occur as a result of chronic use of meth continues to expand based on research. In general, the research studies cited above, NIDA, and the DEA, as well as information taken from The Everything Guide to the Human Brain, indicate that the following cognitive areas are affected significantly as a result of chronic methamphetamine use:

Attention

The term attention is a broad term that encompasses a number of functions, some of them very subtly complicated. Various aspects of attention and concentration are affected by chronic use of methamphetamine as a result of damage that occurs to the neurons in the frontal and prefrontal cortex of the brain. Chronic issues with being able to focus, switch focus, and concentrate for lengthy periods of time often remain even after significant abstinence.

Judgment and Problem-Solving

Like attention the terms judgment and problem–solving are general labels for a number of different cognitive functions, some of which are very complex and occur in multiple steps. The damage that occurs as a result of meth use affects the ability of the individual to suppress impulses, and this may lead to poor judgment and problem-solving. The extent of this dysfunction will vary from individual to individual. Some individuals may become rather impulsive and need quite a bit of assistance initially in controlling their behavior, whereas others may have more subtle deficits.

Memory

Research studies have demonstrated that the ability to encode and recall information is significantly decreased in both animals and humans following chronic methamphetamine use.

Movement Issues

The damage that occurs to a number of the neurons in white matter tracts in the brain is also associated with changes in motor functions, including reaction time, coordination in very subtle and complex skills, and very basic functions, such as walking.

Emotional Control

Related to issues with impulse control is a person’s ability to self-regulate and control emotional states and/or their actual experience of emotions. Individuals who have chronically used methamphetamine demonstrate any number of emotional issues that can mood swings, chronic depression, chronic apathy, a loss of motivation, issues with aggression, hostility, irritability, and even self-harming and/or suicidal behaviors. This reflects both the depletion of neurotransmitters and the structural damage that occurs as a result of chronic methamphetamine use.

Psychological Issues

Individuals who chronically use methamphetamine are more susceptible to the development of severe psychiatric disorders, including issues with psychotic-like behaviors, such as delusions, hallucinations, impaired reality testing, etc. Some of these psychotic-like behaviors can be rather idiosyncratic. For example, the term meth bugs refers to a psychiatric condition where chronic methamphetamine users have a sensation that their skin is crawling or itching with bugs even though no external stimulation is occurring. This condition will often remit but may return spontaneously in some individuals.

Individuals who have pre-existing mental health conditions and have used methamphetamine for lengthy periods of time, resulting in prolonged binges and a lack of attention to self-care, will obviously accrue more damage to the brain and central nervous system compared to individuals who use the drug for shorter or less intense periods or those who have fewer psychiatric issues. It is clear from the research that methamphetamine has the potential to produce lasting effects in anyone who uses it.

Treatment Options for Meth Addiction

Fortunately, meth addiction is treatable. While there are currently no medications approved to treat stimulant use disorders, there are evidence-based treatment approaches that have helped many people achieve long-term sobriety. These include:

• Behavioral therapies, such as cognitive-behavioral therapy (CBT), motivational interviewing (MI), contingency management (CM), and more.
• Psychoeducation.
• Peer support, like 12-Step programs and SMART Recovery.

Getting Help for Meth Addiction

If you or someone you love is struggling with addiction to meth, it’s time to reach out and get the help you deserve. Give us a call at to speak to a compassionate admissions navigator about your treatment options and to begin your recovery journey.

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